Ulster University Researchers Embark on Groundbreaking £1.7m Project
Researchers from Ulster University's Coleraine campus have joined a prestigious £1.7 million UK-wide study funded by the Biotechnology and Biological Sciences Research Council (BBSRC). This four-year initiative, led by King's College London, aims to unlock the mysteries of how plant-based foods influence cardiovascular health. Collaborating with the University of Leeds, the project zeroes in on flavan-3-ols—naturally occurring compounds abundant in everyday foods like tea, cocoa, berries, apples, grapes, nuts, and legumes.
Cardiovascular disease (CVD), encompassing conditions like coronary heart disease and stroke, remains the UK's leading cause of death. According to the British Heart Foundation's Heart & Circulatory Disease Statistics 2025, CVD accounts for around one in six deaths, equating to approximately 110,000 fatalities annually—or one every five minutes. With over 7.6 million people living with heart and circulatory diseases, innovative research into dietary interventions is more critical than ever.
Understanding Flavan-3-ols: Key Players in Plant Foods
Flavan-3-ols are a subclass of flavonoids, potent antioxidants found predominantly in plant-derived foods. These bioactive compounds contribute to the characteristic flavors, colors, and health-promoting properties of items like green tea, dark chocolate, and fresh fruits. Unlike vitamins or minerals, their concentrations can vary significantly based on food processing, storage, and even chewing habits.
Existing evidence from systematic reviews and meta-analyses indicates that flavan-3-ols improve endothelial function—the health of blood vessel linings—and lower blood pressure, key factors in reducing CVD risk. For instance, a comprehensive analysis of randomized controlled trials showed flavan-3-ol-rich interventions significantly enhance flow-mediated dilation, a marker of vascular health.
The Cardiovascular Burden in the United Kingdom
In the UK, CVD prevalence continues to rise, particularly among younger adults under 65, where deaths have increased by 18% since 2019. Lifestyle factors, including diet, play a pivotal role, with poor nutrition contributing to high cholesterol, hypertension, and obesity. Plant-based diets, rich in fiber, antioxidants, and polyphenols like flavan-3-ols, have shown promise in mitigating these risks. Studies suggest healthful plant-based eating patterns can reduce CVD incidence by 19-25%.
Northern Ireland, home to Ulster University, faces similar challenges, with heart disease rates higher than the UK average. This underscores the timeliness of the new study, which could inform targeted public health strategies.
Ulster University's Pivotal Role in the Research
Ulster University, through its Nutrition Innovation Centre for Food and Health (NICHE), brings world-class expertise to the project. Professor Chris Gill, a co-lead investigator and thematic leader for Phytochemicals in Health and Diseases at NICHE, will spearhead human trials using volunteers with ileostomies—surgical openings that bypass the lower gut. This innovative approach allows precise examination of upper gastrointestinal (GI) tract digestion of flavan-3-ols, revealing how these compounds are released and absorbed before reaching the colon.
"The importance of flavan-3-ols and other (poly)phenols to human health continues to evolve," says Professor Gill. "Understanding how these compounds are affected by food processing and the human digestive tract is key to developing a mechanistic understanding of their biological efficacy."
Professor Chris Gill: A Leader in Polyphenol Research
With extensive publications on polyphenols' impact on gut health and endothelial function, Professor Gill's work at Ulster has illuminated how dietary compounds interact with the microbiome to support cardiovascular wellness. His recent reviews highlight (poly)phenol-rich foods' role in improving flow-mediated dilation, a direct measure of vascular health.
- Expertise in phytochemical bioaccessibility and bioavailability.
- Leadership in NICHE, driving translation from lab to policy.
- Collaborations advancing personalized nutrition.
Collaborative Excellence: Partners and Methods
King's College London, under Professor Ana Rodriguez-Mateos, leads with advanced analytical techniques to build a UK flavan-3-ol database. The University of Leeds contributes 'AVATAR' models—personalized gut microbiome simulations cultured from fecal samples—to study individual responses. This multi-faceted approach combines lab models, clinical trials, and population data for robust insights.
The project addresses critical gaps: why do people respond differently to the same foods? How does processing alter bioactivity? Outcomes could personalize dietary advice, optimizing flavan-3-ol intake at 400-600mg daily for benefits.
Innovative Techniques Revolutionizing Nutrition Science
| Method | Purpose | Lead Institution |
|---|---|---|
| Ileostomy trials | Upper GI digestion analysis | Ulster University |
| AVATAR microbiome models | Personalized gut responses | University of Leeds |
| Food composition database | UK intake estimates | King's College London |
| Clinical intervention trial | Cardiometabolic effects | All partners |
These tools promise unprecedented precision, bridging food science and clinical outcomes.
Building on Prior Evidence: Plant Foods and CVD Prevention
Meta-analyses confirm flavan-3-ols from cocoa and tea reduce systolic blood pressure by 2-4mmHg and enhance endothelial function. Healthful plant-based diets correlate with 16-31% lower CVD risk, emphasizing minimally processed sources. Ulster's NICHE has pioneered such findings, influencing global nutrition policy.
Public Health Implications and Future Dietary Guidance
Results could refine UK Eatwell Guide recommendations, promoting flavan-3-ol-rich foods to combat rising CVD. Personalized nutrition, informed by gut microbiome data, may tailor diets for high-risk groups. For Northern Ireland, enhanced research capacity via the £22m Centre of Food and Drug Discovery will accelerate industry collaborations.
Explore the full study details at the Ulster University announcement or King's College London page.
Advancing Higher Education and Research Careers
This project exemplifies UK higher education's role in addressing grand challenges. Ulster's involvement highlights opportunities in nutrition innovation, attracting funding and talent. Aspiring researchers can pursue PhDs in NICHE, focusing on phytochemicals and gut health.
With BBSRC backing, such initiatives bolster university profiles, fostering interdisciplinary careers in biomedical sciences.
Photo by Immo Wegmann on Unsplash
Looking Ahead: Transforming Heart Health Through Science
As the study unfolds over four years, expect breakthroughs that empower individuals with actionable dietary insights. By demystifying plant foods' journey through the body, this collaboration could save lives, reduce NHS burdens, and position UK universities as global leaders in preventive nutrition.
