Research Fellow

Job Purpose

The Research Fellow will lead the development of a Surface-Enhanced Raman Spectroscopy (SERS) biosensor platform for rapid detection of microbial bioburden in biopharmaceutical cleaning validation processes. The role involves aptamer discovery, nanomaterial-based SERS sensor development, and integration with microfluidic systems for real-time monitoring of cleaning validation washout fluids. Opportunities to contribute to patent filings, translational research, and commercialization pathways will be available.

Key Responsibilities

Technical Responsibilities

• Design and screen high-affinity ssDNA aptamers targeting environmental microorganisms listed in the US Pharmacopeia.
• Develop nanoparticle-based SERS substrates (Ag/Au nanoclusters) for enhanced Raman signal detection.
• Design and fabricate microfluidic sensing interfaces for continuous monitoring of cleaning validation fluids.
• Perform sensor validation using Raman spectroscopy, microbial cultures, and cleaning validation samples.
• Develop data analysis pipelines for Raman spectral classification, potentially integrating machine learning methods.

Research & Project Responsibilities

• Plan and execute experimental workflows to achieve project milestones.
• Lead prototype development and performance optimization of the SERS biosensor system.
• Communicate research outcomes through technical reports, conference presentations, and scientific publications.
• Collaborate with industry partners and interdisciplinary research teams where applicable.

Operational Responsibilities

• Conduct risk assessments and ensure compliance with Work Safety and Health (WSH) regulations.
• Manage procurement of specialized equipment and research consumables.

Mentorship

• Mentor research engineers, graduate students, and undergraduate researchers.
• Contribute to training activities within the research group.

Others

• To communicate in any relevant internal or external stakeholders to ensure project deliverables are met.
• Any ad-hoc duties assigned by Supervisor.

Job Requirements

Essential

• PhD in Bioengineering, Chemical Engineering, Materials Science, Nanotechnology, Analytical Chemistry, or related fields.
• Strong publication record in biosensors, nanomaterials, Raman spectroscopy, or microfluidics.
• Demonstrated experience in nanoparticle-based biosensor development or SERS sensing platforms.
• Proficiency in CAD software (e.g., SolidWorks) for microfluidic device design.
• Experience with Raman spectroscopy instrumentation and spectral data analysis.

Preferred

• Experience in microfluidic chip fabrication (soft lithography, PDMS, or micro-machining).
• Experience with aptamer selection or molecular recognition elements.
• Experience applying machine learning to spectral data (Raman, LC–MS, or similar).
• Experience working on translational or industry-linked research projects.