Baby Teeth Stem Cells for Cerebral Palsy: Nagoya University Study
Nagoya University breakthrough: Stem cells from baby teeth (SHED) improve motor and cognitive function in chronic cerebral palsy rat models via HGF-mediated neurogenesis.
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Takahiro Kanzawa is a visiting researcher in the Department of Pediatrics at Nagoya University Graduate School of Medicine and is affiliated with the Division of Neonatology in the Center for Maternal-Neonatal Care at Nagoya University Hospital. He holds an MD and has served as first author on research examining stem cell therapies for cerebral palsy. In a 2026 study published in Stem Cell Research & Therapy, Kanzawa and colleagues demonstrated in a rat model of perinatal hypoxic-ischemic encephalopathy that intravenous administration of human stem cells from exfoliated deciduous teeth (SHED) during the chronic phase improved motor function and learning outcomes. The research showed that SHED migrated to the brain, promoted proliferation of endogenous neural stem cells, and enhanced neurogenesis, with hepatocyte growth factor identified as a key mediator. The work was conducted in collaboration with S-Quatre Corporation and co-authors including Yoshiaki Sato and Yoshiyuki Takahashi.
Kanzawa has presented related research, including at the Pediatric Academic Societies meeting, and continues involvement in studies on regenerative approaches for neonatal and pediatric neurological conditions. His affiliations center on clinical and research activities within Nagoya University’s medical programs focused on neonatology and pediatrics.
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Nagoya University breakthrough: Stem cells from baby teeth (SHED) improve motor and cognitive function in chronic cerebral palsy rat models via HGF-mediated neurogenesis.