CAR-T Cell Therapy Biomarkers: Kyoto U Discovery | AcademicJobs
Kyoto University researchers identify 4MD biomarkers predicting CAR-T therapy success in blood cancers, advancing precision oncology in Japan.
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Takashi Mikami is a Program-specific Assistant Professor in the Division of Cancer Immune Multicellular System Regulation at the Center for Cancer Immunotherapy and Immunobiology, Kyoto University Graduate School of Medicine. He earned his M.D. from the School of Medicine at Hiroshima University in 2012 and his Ph.D. from the Graduate School of Medicine at Kyoto University in 2022. His professional experience includes junior and senior residencies in pediatrics at Kitano Hospital in Osaka from 2012 to 2016, clinical work at Kyoto University Hospital, research fellow positions in the Department of Pediatrics at Kyoto University Graduate School of Medicine from 2021 to 2024, and a research fellowship in the Department of Immunology at Nagoya University Graduate School of Medicine in 2024 before assuming his current role in 2025.
His research centers on cancer immunity in leukemia and other pediatric cancers, with particular emphasis on CD19-targeted immunotherapies and the immune microenvironment in B-cell precursor acute lymphoblastic leukemia. He is a board-certified member and senior fellow of the Japan Pediatric Society and the Japanese Society of Hematology, as well as a member of the Japanese Cancer Association and the Japanese Society of Pediatric Hematology/Oncology. Key publications include a 2026 paper in Cell Reports Medicine on CAR-T cell phenotypes predicting tisagenlecleucel efficacy, a 2025 Nature Communications study on multi-omics analysis of immunosuppressive phenotypes in lineage-switched AML, and earlier works in Blood, Cancer Science, and Pediatric Blood & Cancer addressing topics such as immune alterations in recurrent leukemia and patient-derived xenograft models. His contributions advance understanding of pediatric oncology and immunotherapy approaches.
Kyoto University researchers identify 4MD biomarkers predicting CAR-T therapy success in blood cancers, advancing precision oncology in Japan.
Kyoto University team identifies CD38-CD73-Tim-3-HLA-DR+ biomarkers predicting CAR-T efficacy in BCP-ALL, advancing precision medicine at Japanese universities.