Tissue Regeneration Breakthrough: 50-Year Mystery Solved | AcademicJobs
Discover how Weizmann scientists solved a 50-year mystery in tissue regeneration using DARE cells, with profound implications for cancer therapy and wound healing.
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Dr. Tslil Braun is a Research Associate in the Department of Molecular Genetics at the Weizmann Institute of Science, working in the laboratory of Prof. Eli Arama. Her research focuses on the molecular mechanisms underlying compensatory proliferation and tissue regeneration following damage, using the fruit fly Drosophila melanogaster as a model system. In a 2025 study published in Nature Communications, Braun led a team that identified populations of apoptosis-resistant cells, termed DARE cells, which activate the initiator caspase but survive irradiation and contribute to tissue repair through both cell-autonomous and non-cell-autonomous mechanisms. The work also characterized NARE cells and revealed a negative feedback loop that regulates growth during regeneration, with potential implications for understanding cancer recurrence and treatment resistance.
Braun has contributed to multiple studies from the Arama lab exploring non-lethal roles of apoptotic caspases in development and regeneration. Her professional email address is publicly listed on the Weizmann Institute website.
Discover how Weizmann scientists solved a 50-year mystery in tissue regeneration using DARE cells, with profound implications for cancer therapy and wound healing.