Breakthrough Findings from UCL's BENCHISTA Childhood Cancer Study

A groundbreaking international study led by researchers at University College London (UCL) has shed new light on why childhood cancer survival rates in the UK lag behind some European peers. The research, published in the prestigious JAMA Network Open journal, analyzed nearly 10,000 cases across 27 countries and pinpointed delayed diagnosis as a key factor for lower survival in certain cancers, particularly neuroblastoma. Professor Kathy Pritchard-Jones from UCL's Great Ormond Street Institute of Child Health, a leading expert in paediatric oncology, co-authored the paper as part of the BENCHISTA project, which stands for International Benchmarking of Childhood Cancer Survival by Stage. This collaborative effort with Italy's Fondazione IRCCS Istituto Nazionale dei Tumori (INT) marks the first time population-level data has reliably linked tumour stage at diagnosis to survival variations internationally.

Childhood cancer, though rare—affecting around 1,900 children aged 0-14 in the UK annually—remains the leading cause of death from disease in children over one year old. Overall five-year survival in Great Britain stands at 84%, a remarkable improvement from 77% in 2001, thanks to advances in treatment and research. However, disparities persist, with the BENCHISTA study revealing that for some solid tumours, UK children are diagnosed at more advanced stages, reducing their three-year overall survival (OS) chances.

The study's scope is impressive: 9,883 cases from 73 population-based cancer registries, diagnosed between 2014 and 2017, focusing on six common solid childhood cancers. By standardizing staging using the Toronto Childhood Cancer Stage Guidelines, researchers achieved over 90% completeness in stage data, enabling true apples-to-apples comparisons.

Six Childhood Cancers Under the Microscope: Survival by Stage

The BENCHISTA project examined neuroblastoma, Wilms tumour, medulloblastoma, osteosarcoma, Ewing sarcoma, and rhabdomyosarcoma—representing a significant portion of childhood solid tumours. Across all, three-year OS dropped sharply with advancing stage. For instance, Wilms tumour (kidney cancer) boasted 95% OS overall (95% CI 94-96%), with stage I at nearly 99% versus 87% for stage IV. Neuroblastoma survival was 83% (81-84%), while osteosarcoma lagged at 75% (73-77%).

• Neuroblastoma: A tumour originating in immature nerve cells, often in the adrenal glands; affects ~100 UK children yearly, mostly under five.
• Wilms Tumour: Kidney cancer, highly curable if caught early.
• Medulloblastoma: Aggressive brain tumour, 79% OS.
• Osteosarcoma and Ewing Sarcoma: Bone cancers, 75-78% OS.
• Rhabdomyosarcoma: Soft tissue cancer, 77% OS.

These statistics underscore how stage dictates prognosis: localized tumours have near-perfect survival, but metastatic cases plummet, e.g., rhabdomyosarcoma stage I 95% vs metastatic 45%. UCL's rigorous methodology highlights the institute's prowess in global health research.

UK Lags Behind Central Europe: Regional Disparities Exposed

Using Central Europe (Austria, Belgium, France, Germany, Netherlands, Switzerland) as benchmark, the study found significant three-year OS variations for four cancers. UK and Ireland showed lower survival for neuroblastoma, fully explained by higher proportions of advanced-stage diagnoses. Hazard ratio (HR) age-adjusted 1.31 mitigated post-stage adjustment (HR 1.18, 95% CI 0.91-1.52).

Ewing sarcoma metastatic survival was stark: UK/Ireland 36% (23-49%) vs Central Europe's 71% (61-79%). Eastern Europe faced similar issues. For more on European collaborations, explore UCL Great Ormond Street Institute.

This data positions UK universities like UCL at the forefront of addressing national health challenges through evidence-based research. Aspiring researchers can find opportunities in higher education research jobs.

Neuroblastoma Focus: Why Delays Cost Lives in the UK

Neuroblastoma exemplifies the diagnosis delay problem. Nine in ten cases strike children under five, with half high-risk at diagnosis. In the UK, later staging leads to poorer outcomes compared to Central Europe. Prof. Pritchard-Jones noted: "We have provided unbiased evidence for later diagnosis of some childhood cancers in the UK and Ireland."

Recent University of Nottingham research corroborates longer waits for bone tumours and teens. NHS National Cancer Plan aims to counter this with awareness and specialist access.

Photo by David Trinks on Unsplash

UCL Great Ormond Street Institute: Powerhouse of Child Health Research

UCL's Great Ormond Street Institute of Child Health, Europe's largest child health research centre, drives innovations like BENCHISTA. Prof. Pritchard-Jones, Professor of Paediatric Oncology, leads efforts with over 500 publications cited 34,000+ times. Her work spans SIOP presidency and DATA-CAN clinical lead. The institute secured £88m in 2024/25 grants, powering breakthroughs.

Funding from Children with Cancer UK (£300m+ raised) and NIHR underscores public-private synergy. Careers here blend academia and clinical impact—check research assistant jobs or academic CV tips.

BENCHISTA Methodology: Setting New Standards in Oncology Data

BENCHISTA revolutionized data via 18-month training on Toronto guidelines, achieving 93% stage completeness. Retrospective cohort: 0-14/17 years, 3-year follow-up, Cox models for HRs. Limitations: small cases per region, 3-year OS. Full study: JAMA Network Open.

Policy Implications and Stakeholder Voices

Dr Laura Botta (INT): "Findings guide health policies to save lives." Charities like CCLG push 'Child Cancer Smart' for GP/parent tools. NHS pledges early detection via National Cancer Plan. Parent Angela Polanco: "Timely diagnosis reduces inequalities."

UK higher ed must bolster such research; see UK university jobs.

Future Outlook: Phase II and Beyond

BENCHISTA Phase II examines 5-year survival, treatments. Global trends: 84% UK survival, but gaps persist. Solutions: awareness, data standardization, trials access. UCL exemplifies how university research drives policy—opportunities in postdoc positions.

Photo by Roman Kraft on Unsplash

Careers in Paediatric Oncology Research: Join the Fight

UK universities seek experts in child health. From lecturer to professor roles, contribute like Prof. Pritchard-Jones. Explore lecturer jobs, professor jobs, or career advice. Internal links to Rate My Professor for insights.

In conclusion, UCL's study calls for action. Share experiences on comments, apply to higher ed jobs, university jobs.